Endothelial Keratoplasty of the Descemet Membrane in Uveal Melanoma Patients Following Radiation Treatment - Takeaways - MDSpire

Endothelial Keratoplasty of the Descemet Membrane in Uveal Melanoma Patients Following Radiation Treatment

  • By

  • Anna-Karina B. Maier

  • Dhoksina Papa

  • Aline Riechardt

  • Jens Heufelder

  • Oliver Zeitz

  • Antonia M. Joussen

  • Tina Dietrich-Ntoukas

  • April 2, 2026

  • 0 min

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  • 1

    Uveal melanoma is the most common primary intraocular tumor in adults, with treatment options including resection, radiation, and enucleation.

  • 2

    Descemet membrane endothelial keratoplasty (DMEK) is effective for treating corneal endothelial disorders post-radiation therapy in uveal melanoma patients.

  • 3

    In a study of 9 patients, visual acuity improved significantly after DMEK surgery, although some patients had limiting factors affecting outcomes.

  • 4

    Endothelial cell density of grafts decreased over time, indicating potential challenges in long-term graft health after DMEK.

  • 5

    Complications from uveal melanoma treatment, such as glaucoma and corneal decompensation, may impact the success of DMEK procedures.

Original Source(s)

Endothelial Keratoplasty of the Descemet Membrane in Uveal Melanoma Patients Following Radiation Treatment

  • by Anna-Karina B. Maier, Dhoksina Papa, Aline Riechardt, Jens Heufelder, Oliver Zeitz, Antonia M. Joussen, Tina Dietrich-Ntoukas

  • April 2, 2026

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