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1
After ICU rooms were converted from positive to negative pressure, probable or proven pulmonary aspergillosis occurred in 6 of 26 patients, and 2 others were colonized by Aspergillus fumigatus.
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2
Air sampling detected A fumigatus in rooms of affected patients, and airborne concentrations fell after disinfection and pressure changes, although antifungal prophylaxis confounded attribution.
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3
In Kreitmann et al’s observational study of 1233 mechanically ventilated patients across 75 ICUs, negative-pressure room exposure was associated with lower 60-day probable IPA incidence under FUNDICU
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4
Mycological testing was less frequent among patients in negative-pressure rooms, potentially contributing to underdiagnosis and limiting interpretation of the lower probable IPA incidence.
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5
The authors argue that room design, anterooms, pressure gradients, ventilation, filtration, and environmental fungal surveillance should be assessed when evaluating negative-pressure ICU rooms.
