Early in-hospital initiation of angiotensin-receptor–neprilysin inhibitor in post-acute myocardial infarction patients with impaired left ventricular systolic function: a systematic review and meta-analysis of randomized controlled trials - Takeaways - MDSpire

Initiating Angiotensin-Receptor–Neprilysin Inhibitors Early in Hospitalized Patients with Impaired Left Ventricular Systolic Function Post-Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Trials

  • By

  • Quynh Nguyen

  • Trang Thi Quynh Tran

  • Chia-Te Liao

  • Chung-Lieh Hung

  • Hung-Yu Chang

  • Chih-Wei Chen

  • Yi-Cheng Lin

  • Chun-Yao Huang

  • Chien-Yi Hsu

  • July 21, 2026

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  • 1

    Early in-hospital initiation of ARNI therapy significantly reduces major adverse cardiovascular events in post-AMI patients with impaired left ventricular systolic function.

  • 2

    ARNI therapy improves left ventricular ejection fraction and reduces NT-proBNP levels compared to ACE inhibitors or ARBs.

  • 3

    Patients receiving ARNI experienced higher rates of adverse events, primarily symptomatic hypotension, compared to those on ACE inhibitors or ARBs.

  • 4

    The systematic review included 12 randomized controlled trials with a total of 7,539 patients and a mean follow-up of approximately 6 months.

  • 5

    Results indicate that early ARNI adoption in high-risk post-AMI patients may provide significant cardiovascular benefits.

Original Source(s)

Early in-hospital initiation of angiotensin-receptor–neprilysin inhibitor in post-acute myocardial infarction patients with impaired left ventricular systolic function: a systematic review and meta-analysis of randomized controlled trials

  • by Quynh Nguyen, Trang Thi Quynh Tran, Chia-Te Liao, Chung-Lieh Hung, Hung-Yu Chang, Chih-Wei Chen, Yi-Cheng Lin, Chun-Yao Huang, Chien-Yi Hsu

  • July 21, 2026

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