Innate-immune crosstalk orchestrates T cell-mediated rejection in kidney transplants - Takeaways - MDSpire

Innate-immune crosstalk orchestrates T cell-mediated rejection in kidney transplants

  • By

  • Yuyun Hu

  • Zhiqiang Chen

  • Yujun Liang

  • Zhixuan Wu

  • Yijian Zhang

  • Junyu Guo

  • Chunqiang Dong

  • Guanmiao Chen

  • Michael Williams

  • Emily Johnson

  • Min He

  • Wei Du

  • Boqian Wang

  • July 7, 2026

  • 0 min

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  • 1

    T cell–mediated rejection (TCMR) is a significant barrier to long-term kidney allograft survival due to recipient immune responses against donor antigens.

  • 2

    The study utilized single-cell RNA sequencing to create a comprehensive atlas of immune cell populations in kidney allograft biopsies.

  • 3

    Key findings included the identification of activated cell subsets, such as NQO1+NDUFS4+ proximal tubular and S100A8+ macrophages, associated with TCMR.

  • 4

    Innate immune cells were found to enhance adaptive immune responses through chemokine and inflammatory signaling networks.

  • 5

    The DUSP1+ effector CD8+ T cell subset was enriched in TCMR and may play a role in graft injury via the B2M/MHC class I axis.

Original Source(s)

Innate-immune crosstalk orchestrates T cell-mediated rejection in kidney transplants

  • by Yuyun Hu, Zhiqiang Chen, Yujun Liang, Zhixuan Wu, Yijian Zhang, Junyu Guo, Chunqiang Dong, Guanmiao Chen, Michael Williams, Emily Johnson, Min He, Wei Du, Boqian Wang

  • July 7, 2026

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