H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation - Takeaways - MDSpire

H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation

  • By

  • Cher Bass

  • Foivos Ntelemis

  • Julian Schmidt

  • Steffen Wolf

  • André Geraldes

  • Debapriya Mehrotra

  • Shikha Singhal

  • Narender Kumar

  • Angelica Marcia

  • Nicholas Bennett

  • Oscar Maiques

  • Mitchell Hyde

  • Bejal Mistry

  • Grace Rogerson

  • Michele Cummings

  • Clare Freer

  • Elizabeth Walsh

  • Manuel Salto-Tellez

  • Maurice Loughrey

  • In Hwa Um

  • David J. Harrison

  • Richard Clarkson

  • James Blackwood

  • J. Carl Barrett

  • Jakob Nikolas Kather

  • Nicolas M. Orsi

  • Pahini Pandya

  • Salim Arslan

  • December 15, 2025

  • 0 min

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  • 1

    Mismatch repair deficiency occurs in 10-20% of colorectal cancer cases, leading to microsatellite instability, which is critical for patient management.

  • 2

    The PANProfiler Colorectal (PPC) test uses AI to determine MSI/MMR status from H&E-stained slides, offering a cost-effective alternative to traditional methods.

  • 3

    In a blinded multi-center study, PPC achieved an overall agreement of 93.83% in determining MSI/MMR status from 3,576 whole slide images.

  • 4

    PPC produced definitive results for 86.55% of slides, demonstrating high positive and negative agreement rates of 92.54% and 94.02%, respectively.

  • 5

    The study supports PPC's potential to streamline CRC diagnostics, improving turnaround times and accessibility for MSI/MMR testing.

Original Source(s)

H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation

  • by Cher Bass, Foivos Ntelemis, Julian Schmidt, Steffen Wolf, André Geraldes, Debapriya Mehrotra, Shikha Singhal, Narender Kumar, Angelica Marcia, Nicholas Bennett, Oscar Maiques, Mitchell Hyde, Bejal Mistry, Grace Rogerson, Michele Cummings, Clare Freer, Elizabeth Walsh, Manuel Salto-Tellez, Maurice Loughrey, In Hwa Um, David J. Harrison, Richard Clarkson, James Blackwood, J. Carl Barrett, Jakob Nikolas Kather, Nicolas M. Orsi, Pahini Pandya, Salim Arslan

  • December 15, 2025

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