Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours - Takeaways - MDSpire

Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours

  • By

  • Cheng Wen

  • Jieling Ma

  • Lijuan Zhang

  • Liping Yang

  • Xiaoxue Luo

  • Ling Yan

  • June 8, 2026

  • 0 min

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  • 1

    A nomogram was developed to predict hospital-acquired ESKAPE colonization or infection in very preterm infants using early clinical indicators.

  • 2

    The study involved 465 very preterm infants, with 77 (16.56%) developing ESKAPE colonization or infection within 14 days after birth.

  • 3

    Key predictors included gestational age, initial invasive mechanical ventilation, vasoactive exposure, and 5-minute Apgar score.

  • 4

    The nomogram demonstrated moderate discrimination with an AUC of 0.786 in the training cohort and 0.770 in the validation cohort.

  • 5

    External validation and prospective studies are necessary before the nomogram can be routinely adopted in clinical practice.

Original Source(s)

Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours

  • by Cheng Wen, Jieling Ma, Lijuan Zhang, Liping Yang, Xiaoxue Luo, Ling Yan

  • June 8, 2026

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