Comparison of 68Ga-FAPI and 18F-DOPA PET/CT in patients with medullary thyroid cancer

1

This study compared 68Ga-FAPI PET/CT with 18F-DOPA PET/CT for detecting metastases in medullary thyroid carcinoma patients.
2

Nine patients with a mean age of 55 years and 62 lesions were analyzed in this retrospective study.
3

68Ga-FAPI demonstrated significantly higher detection rates for lymph node, lung, and liver metastases compared to 18F-DOPA.
4

The true-positive rates for lymph node, lung, and liver metastases were 100%, 85.7%, and 100% for 68Ga-FAPI, respectively.
5

68Ga-FAPI PET/CT showed higher tumor-to-background ratios than 18F-DOPA, indicating improved imaging potential for MTC.

Frontiers In Endocrinology

by Daniel A. Hescheler, Dogan Atiyat, Kerstin Lorenz, Alexander Heinzel, Philipp Reschke, Frankis G. Almaguel, Manuela Petersen, Elisabeth Eppard, Joanna Wybranska, Jan Wuestemann, Michael C. Kreissl
June 24, 2026

1