Prior vedolizumab exposure and fibroblast-derived MMP13 are associated with ustekinumab nonresponse in ulcerative colitis - Takeaways - MDSpire
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Association of Previous Vedolizumab Treatment and Fibroblast-Derived MMP13 with Nonresponse to Ustekinumab in Ulcerative Colitis Patients

  • By

  • Yuiko Tsuruta

  • Yoki Furuta

  • Masatoshi Nakashima

  • Cheng Pan

  • Shota Takano

  • Koichi Sakurai

  • Hideki Kitada

  • Kana Omoto

  • Taichi Matsuyama

  • Yoshinari Sakai

  • Suguru Chiyonaga

  • Kotaro Fukubayashi

  • Takashi Shono

  • Masakuni Tateyama

  • Kotaro Waki

  • Munenori Honda

  • Kenshi Matsuno

  • Akira Yamasaki

  • Hideaki Miyamoto

  • Ryosuke Gushima

  • Takehisa Watanabe

  • Katsuya Nagaoka

  • Hideaki Naoe

  • Yoshihiro Komohara

  • Yasuhito Tanaka

  • September 28, 2026

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  • 1

    Ulcerative colitis is a chronic inflammatory disorder requiring effective treatment strategies beyond corticosteroids.

  • 2

    Ustekinumab has shown efficacy in moderate-to-severe ulcerative colitis, but previous therapy exposure's impact on its effectiveness is unclear.

  • 3

    This study evaluates the influence of prior vedolizumab treatment on clinical response to ustekinumab in ulcerative colitis patients.

  • 4

    The study is a multicenter, observational analysis conducted across 11 institutions in Japan, involving patients aged 14-84.

  • 5

    Clinical outcomes were assessed at 2, 6, and 12 months post-ustekinumab initiation, focusing on response and remission rates.

Original Source(s)

Prior vedolizumab exposure and fibroblast-derived MMP13 are associated with ustekinumab nonresponse in ulcerative colitis

  • by Yuiko Tsuruta, Yoki Furuta, Masatoshi Nakashima, Cheng Pan, Shota Takano, Koichi Sakurai, Hideki Kitada, Kana Omoto, Taichi Matsuyama, Yoshinari Sakai, Suguru Chiyonaga, Kotaro Fukubayashi, Takashi Shono, Masakuni Tateyama, Kotaro Waki, Munenori Honda, Kenshi Matsuno, Akira Yamasaki, Hideaki Miyamoto, Ryosuke Gushima, Takehisa Watanabe, Katsuya Nagaoka, Hideaki Naoe, Yoshihiro Komohara, Yasuhito Tanaka

  • September 28, 2026

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