Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation - Takeaways - MDSpire

Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation

  • By

  • Thomas P. Buters

  • Digna T. de Bruin

  • Pieter W. Hameeteman

  • Wouter ten Voorde

  • Hendrika W. Grievink

  • Michelle Osse

  • Marieke L. de Kam

  • Jeffrey Damman

  • Thierry P. P. van den Bosch

  • Elsa Neubert

  • Robert Rissmann

  • Jacobus Burggraaf

  • Naomi Klarenbeek

  • Manon A. A. Jansen

  • Matthijs Moerland

  • May 20, 2026

  • 0 min

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  • 1

    Intradermal lipopolysaccharide (LPS) administration effectively models TLR4-mediated inflammation in human skin.

  • 2

    The study assessed early immune responses to LPS, focusing on IL-1β, neutrophil infiltration, NET formation, and inflammasome activation.

  • 3

    Prednisolone reduced vascular responses and intermediate monocyte infiltration but did not significantly affect early neutrophil responses or cytokine levels.

  • 4

    Neutrophil influx and NET formation were observed as early as 1 hour post-LPS injection, with peak NET formation at 24 hours.

  • 5

    The findings highlight the intradermal LPS model's utility for studying early innate immune responses and evaluating anti-inflammatory therapies.

Original Source(s)

Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation

  • by Thomas P. Buters, Digna T. de Bruin, Pieter W. Hameeteman, Wouter ten Voorde, Hendrika W. Grievink, Michelle Osse, Marieke L. de Kam, Jeffrey Damman, Thierry P. P. van den Bosch, Elsa Neubert, Robert Rissmann, Jacobus Burggraaf, Naomi Klarenbeek, Manon A. A. Jansen, Matthijs Moerland

  • May 20, 2026

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