Association between combined allergic rhinitis and asthma syndrome in children and nitric oxide: mechanisms, clinical significance, and research progress - Takeaways - MDSpire
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Linking Combined Allergic Rhinitis and Asthma Syndrome in Pediatric Patients to Nitric Oxide: Insights into Mechanisms, Clinical Implications, and Research Developments

  • By

  • Kai Chen

  • Haonan Lin

  • August 21, 2026

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  • 1

    Combined allergic rhinitis and asthma syndrome (CARAS) is a prevalent chronic inflammatory airway disorder in children.

  • 2

    Research indicates a significant relationship between fractional exhaled nitric oxide (FeNO) and the pathogenesis of CARAS in pediatric patients.

  • 3

    The NO/cGMP signaling pathway and nitrosative stress are key mechanisms involved in the progression of CARAS in children.

  • 4

    Exhaled nitric oxide serves as a non-invasive biomarker for diagnosing and monitoring CARAS in pediatric patients.

  • 5

    Current treatments for CARAS primarily include antihistamines and inhaled corticosteroids, which may have adverse effects.

Original Source(s)

Association between combined allergic rhinitis and asthma syndrome in children and nitric oxide: mechanisms, clinical significance, and research progress

  • by Kai Chen, Haonan Lin

  • August 21, 2026

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