Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease - Takeaways - MDSpire

Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease

  • By

  • Seonghwan Kim

  • Soobin Lee

  • Soyeon Ju

  • Jaewoong Bae

  • Jin Suk Ryu

  • Yerim Heo

  • Wan Jae Choi

  • Kum-Joo Shin

  • Seok-Jin Kim

  • Namphil Kim

  • Hansol Choi

  • Jiyun Park

  • Eunjae Lee

  • Chang Ho Yoon

  • Sunghoon Kwon

  • Junho Chung

  • Mee Kum Kim

  • June 16, 2026

  • 0 min

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  • 1

    The study investigates the role of gut microbiota in the pathogenesis of Sjögren disease using a mouse model.

  • 2

    Fecal microbiota transplantation from autoimmune dry eye model mice to B6 mice resulted in significant changes in gut microbiome composition.

  • 3

    NOD-FMT mice exhibited Sjögren disease-like clinical features, including increased corneal fluorescein staining and reduced tear production.

  • 4

    Stereotypic B cell receptor clonotypes were found at higher frequencies in NOD-FMT mice, indicating altered immune responses.

  • 5

    The findings suggest a gut–ocular immune axis where microbiota transfer influences B cell receptor profiles and disease development.

Original Source(s)

Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease

  • by Seonghwan Kim, Soobin Lee, Soyeon Ju, Jaewoong Bae, Jin Suk Ryu, Yerim Heo, Wan Jae Choi, Kum-Joo Shin, Seok-Jin Kim, Namphil Kim, Hansol Choi, Jiyun Park, Eunjae Lee, Chang Ho Yoon, Sunghoon Kwon, Junho Chung, Mee Kum Kim

  • June 16, 2026

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