Impact of diabetes mellitus on mortality in patients with acute exacerbation of chronic obstructive Pulmonary disease: a meta-analysis and systematic review - Takeaways - MDSpire

Impact of diabetes mellitus on mortality in patients with acute exacerbation of chronic obstructive Pulmonary disease: a meta-analysis and systematic review

  • By

  • Dongmei Zhang

  • Hongbo Zhou

  • Xiujuan Yang

  • Dajian Xia

  • May 13, 2026

  • 0 min

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  • 1

    Diabetes mellitus significantly increases mortality risk in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

  • 2

    The meta-analysis included 9 studies with 23,883 subjects, revealing a hazard ratio of 1.45 for diabetes-related mortality in AECOPD patients.

  • 3

    Subgroup analysis indicated that diabetes heightened mortality risk in hospitalized AECOPD patients but not in those in intensive care units.

  • 4

    The study found no independent correlation between diabetes and mortality risk in multivariate analysis, suggesting confounding factors may obscure results.

  • 5

    Further well-structured prospective cohort studies are necessary to clarify the prognostic impact of diabetes on mortality in AECOPD patients.

Original Source(s)

Impact of diabetes mellitus on mortality in patients with acute exacerbation of chronic obstructive Pulmonary disease: a meta-analysis and systematic review

  • by Dongmei Zhang, Hongbo Zhou, Xiujuan Yang, Dajian Xia

  • May 13, 2026

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