Oxidized Polyunsaturated Fatty Acid Promotes Colitis and Colitis-Associated Tumorigenesis in Mice

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Oxidized polyunsaturated fatty acids (PUFAs) increase the severity of colitis and promote tumor development in murine models.
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A diet rich in unoxidized PUFAs does not exacerbate colitis, indicating that oxidized PUFAs are the harmful variant.
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Oxidized PUFAs worsen intestinal barrier dysfunction and enhance bacterial translocation in mice.
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The effects of oxidized PUFAs on colitis are mediated through Toll-like receptor 4 (TLR4) and gut microbiota.
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Findings suggest a need to revise regulations on oxidized PUFA levels in food due to their potential health risks.

Journal Of Crohn's And Colitis

by Weicang Wang, Yuxin Wang, Katherine Z Sanidad, Yige Wang, Jianan Zhang, Wenqi Yang, Quancai Sun, Ipek Bayram, Renhua Song, Haixia Yang, David Johnson, Heather L Sherman, Daeyoung Kim, Lisa M Minter, Justin J-L Wong, Melody Y Zeng, Eric A Decker, Guodong Zhang
September 16, 2024

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