Factors Affecting Significant Breast Edema in Breast Cancer Patients Receiving Breast-Conserving Surgery and Radiotherapy with Deep Inspiration Breath Hold - Takeaways - MDSpire

Factors Affecting Significant Breast Edema in Breast Cancer Patients Receiving Breast-Conserving Surgery and Radiotherapy with Deep Inspiration Breath Hold

  • By

  • Yong Sang

  • Xiaoye Su

  • Nan Hu

  • Jianan Wu

  • Lijuan Huang

  • Jing Jin

  • Qin Xiao

  • April 24, 2026

  • 0 min

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  • 1

    Breast edema (BE) is a common complication after breast-conserving surgery (BCS) and radiotherapy in early-stage breast cancer patients.

  • 2

    Significant breast edema (SBE) is defined as a dimensional increase of ≥5 mm in the breast during radiotherapy, impacting treatment planning.

  • 3

    PTVboost volume was identified as the only independent factor significantly associated with increased risk of SBE during radiotherapy.

  • 4

    The optimal cutoff value for PTVboost volume predicting SBE was determined to be 107.5 cc, with a sensitivity of 80% and specificity of 56%.

  • 5

    Proactive management of SBE is recommended in BCS patients during radiotherapy to improve treatment accuracy and patient quality of life.

Original Source(s)

Factors Affecting Significant Breast Edema in Breast Cancer Patients Receiving Breast-Conserving Surgery and Radiotherapy with Deep Inspiration Breath Hold

  • by Yong Sang, Xiaoye Su, Nan Hu, Jianan Wu, Lijuan Huang, Jing Jin, Qin Xiao

  • April 24, 2026

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