Accuracy of corticospinal tract reconstruction: DTI-based deterministic versus probabilistic tractography with intraoperative validation - Takeaways - MDSpire

Accuracy of corticospinal tract reconstruction: DTI-based deterministic versus probabilistic tractography with intraoperative validation

  • By

  • Roberto Altieri

  • Lorenzo Ugga

  • Ferdinando Caranci

  • Ciro De Luca

  • Giuseppe La Rocca

  • Daniela Pacella

  • Manlio Barbarisi

  • May 15, 2026

  • 0 min

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  • 1

    Preoperative mapping of the corticospinal tract is essential for preserving motor function during brain tumor surgery.

  • 2

    Probabilistic tractography demonstrated greater accuracy in distance measurements compared to deterministic tractography during intraoperative validation.

  • 3

    The mean stimulation threshold for direct electrical stimulation was 9.83 mA, with probabilistic tractography showing a mean distance of 12.01 mm.

  • 4

    Deterministic tractography significantly overestimated distances, with a mean difference of -17.9 mm compared to direct electrical stimulation.

  • 5

    Combining probabilistic tractography with direct electrical stimulation enhances surgical safety and optimizes tumor resection while minimizing motor deficits.

Original Source(s)

Accuracy of corticospinal tract reconstruction: DTI-based deterministic versus probabilistic tractography with intraoperative validation

  • by Roberto Altieri, Lorenzo Ugga, Ferdinando Caranci, Ciro De Luca, Giuseppe La Rocca, Daniela Pacella, Manlio Barbarisi

  • May 15, 2026

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