High Rates of Bacteremia and Fluoroquinolone Resistance During an Outbreak of Shigellosis Among People Experiencing Homelessness and Opioid Use Disorder in Philadelphia, Pennsylvania - Takeaways - MDSpire

High Rates of Bacteremia and Fluoroquinolone Resistance During an Outbreak of Shigellosis Among People Experiencing Homelessness and Opioid Use Disorder in Philadelphia, Pennsylvania

  • By

  • Eleanor Stedman

  • Andrea Molin

  • Valencia Oglesby

  • Erin Torpey

  • Stephanie Spivack

  • Kaede V Sullivan

  • Sara Schultz

  • May 16, 2025

  • 0 min

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  • 1

    In 2023, Philadelphia experienced an outbreak of Shigella flexneri infections, with 67 hospitalized patients.

  • 2

    Among hospitalized patients, 31.3% were bacteremic, indicating a high incidence of severe disease.

  • 3

    Most affected individuals had housing insecurity and opioid use disorder, highlighting social determinants of health.

  • 4

    Trimethoprim-sulfamethoxazole was the only antibiotic with reliable susceptibility against the multidrug-resistant strains.

  • 5

    The outbreak resulted in one death, marking a case fatality rate of 1.49% among hospitalized patients.

Original Source(s)

High Rates of Bacteremia and Fluoroquinolone Resistance During an Outbreak of Shigellosis Among People Experiencing Homelessness and Opioid Use Disorder in Philadelphia, Pennsylvania

  • by Eleanor Stedman, Andrea Molin, Valencia Oglesby, Erin Torpey, Stephanie Spivack, Kaede V Sullivan, Sara Schultz

  • May 16, 2025

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