Maresin-1 and maresin-2 as synovial fluid biomarkers in psoriatic, rheumatoid, and osteoarthritis - Takeaways - MDSpire

Maresin-1 and maresin-2 as synovial fluid biomarkers in psoriatic, rheumatoid, and osteoarthritis

  • By

  • Sukru Demir

  • Bugra Can

  • Omer Esmez

  • Mustafa Ata Aydin

  • Sevval Yagmur Gencer

  • Furkan Bildirici

  • Süleyman Serdar Koca

  • İbrahim Sahin

  • Suleyman Aydin

  • July 14, 2026

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  • 1

    The study included 88 patients with psoriatic arthritis, rheumatoid arthritis, osteoarthritis, and healthy controls undergoing knee arthrocentesis.

  • 2

    Maresin-1 levels were significantly higher in psoriatic arthritis patients compared to rheumatoid arthritis patients, with p < 0.01.

  • 3

    Receiver operating characteristic analysis showed Maresin-1 had an area under the curve of 0.815 for distinguishing psoriatic arthritis from rheumatoid arthritis.

  • 4

    A cut-off value of 3.252 ng/mL for Maresin-1 provided 68.2% sensitivity and 86.4% specificity in differentiating psoriatic arthritis from rheumatoid arthritis.

  • 5

    Maresin-2 levels showed more modest differences among groups, indicating its clinical significance may be limited and requires further validation.

Original Source(s)

Maresin-1 and maresin-2 as synovial fluid biomarkers in psoriatic, rheumatoid, and osteoarthritis

  • by Sukru Demir, Bugra Can, Omer Esmez, Mustafa Ata Aydin, Sevval Yagmur Gencer, Furkan Bildirici, Süleyman Serdar Koca, İbrahim Sahin, Suleyman Aydin

  • July 14, 2026

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