Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines - Takeaways - MDSpire

Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines

  • By

  • Erica J Weinstein

  • Dean M Carbonari

  • Craig W Newcomb

  • Jessie Torgersen

  • Shanae M Smith

  • Katherine L Brecker

  • X Sherry Liu

  • Jay R Kostman

  • Stacey Trooskin

  • Rebecca A Hubbard

  • Joshua F Baker

  • Babette S Zemel

  • Mary B Leonard

  • Vincent Lo Re

  • April 29, 2025

  • 0 min

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  • 1

    Chronic hepatitis C virus (HCV) infection is linked to reduced bone mineral density (BMD) and increased fracture risk.

  • 2

    Participants with chronic HCV exhibited lower trabecular and cortical volumetric BMD compared to those without HCV.

  • 3

    Higher levels of tumor necrosis factor α (TNF-α) were found in chronic HCV patients, correlating with lower bone density.

  • 4

    The study utilized high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess bone microarchitecture.

  • 5

    Findings suggest that HCV-associated inflammation may contribute to skeletal fragility and warrant further investigation.

Original Source(s)

Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines

  • by Erica J Weinstein, Dean M Carbonari, Craig W Newcomb, Jessie Torgersen, Shanae M Smith, Katherine L Brecker, X Sherry Liu, Jay R Kostman, Stacey Trooskin, Rebecca A Hubbard, Joshua F Baker, Babette S Zemel, Mary B Leonard, Vincent Lo Re

  • April 29, 2025

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