A pharmacodynamic study of rapid lactate metabolic modulation by intravenous L-arginine in brain metastases - Takeaways - MDSpire

A pharmacodynamic study of rapid lactate metabolic modulation by intravenous L-arginine in brain metastases

  • By

  • Xueping Liu

  • Guobo Du

  • Nai Mu

  • Lang He

  • May 28, 2026

  • 0 min

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  • 1

    Intravenous L-arginine significantly reduces lactate levels in brain metastases, with a peak effect observed at approximately 30 minutes post-infusion.

  • 2

    The study involved 20 patients randomized to receive normal saline or varying doses of L-arginine (10 g, 20 g, or 30 g) to assess lactate metabolism.

  • 3

    The 30 g dose of L-arginine resulted in the most substantial lactate reduction, achieving a peak decrease of 63.5% at 30 minutes.

  • 4

    No treatment-related adverse events were reported within 24 hours following the intravenous L-arginine infusion.

  • 5

    The findings support further investigation of L-arginine as a radiosensitizer in future phase II clinical trials.

Original Source(s)

A pharmacodynamic study of rapid lactate metabolic modulation by intravenous L-arginine in brain metastases

  • by Xueping Liu, Guobo Du, Nai Mu, Lang He

  • May 28, 2026

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