Distinct Monocyte State Linked to Fatigue and Pulmonary Impairment in Long COVID

Single-cell profiling reveals persistent immune alterations associated with fatigue severity and impaired lung function.

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A distinct immune cell state linked to long COVID was identified, explaining persistent fatigue and respiratory impairment.
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The study found a CD14-positive monocyte transcriptional state, termed LC-Mo, associated with long COVID symptoms.
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Elevated cytokines CCL2, CXCL11, and TNF were observed for up to 9 months post-infection, indicating ongoing immune activation.
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Higher LC-Mo expression correlated with increased fatigue and poorer respiratory outcomes in long COVID patients.
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The findings suggest a mechanistic link between immune dysfunction and lung remodeling, highlighting potential therapeutic targets.

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