Tight junction-related proteins in the upper reproductive tract luminal and glandular epithelial cells are regionally regulated across the estrous cycle - Takeaways - MDSpire
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Regional Regulation of Tight Junction Proteins in Luminal and Glandular Epithelial Cells of the Upper Reproductive Tract Throughout the Estrous Cycle

  • By

  • Donaldson A. Magloire

  • Haoming Liu

  • Heather L. Wilson

  • August 17, 2026

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  • 1

    The study evaluates the expression of Tight Junction proteins Claudin-3, Claudin-4, and ZO-1 in the porcine upper reproductive tract during estrus and diestrus.

  • 2

    Claudin-4 expression significantly decreased in the distal uterine horn during estrus, while levels remained stable in the cervix across estrous stages.

  • 3

    Claudin-3 showed a marked reduction during estrus in the glandular epithelium of the distal uterine horn and cervical luminal epithelium.

  • 4

    The expression of ZO-1 remained largely unaffected by the estrous stage in all examined regions of the upper reproductive tract.

  • 5

    The findings indicate that the regulation of Claudin-3 and Claudin-4 is stage-dependent and region-specific within the porcine reproductive tract.

Original Source(s)

Tight junction-related proteins in the upper reproductive tract luminal and glandular epithelial cells are regionally regulated across the estrous cycle

  • by Donaldson A. Magloire, Haoming Liu, Heather L. Wilson

  • August 17, 2026

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