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Mass Spec Roundup: Pressure, Phosphorylation, and Profiling
New approaches improve Orbitrap CDMS, uncover broad T7 kinase activity, develop a targeted urine signature for kidney cancer, and unite exposure quantification with metabolomics.
A pulsed gas valve enhances stability in Orbitrap measurements, improving mass determination for large biomolecules like viruses and plasmids.
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The study demonstrated that pressure modulation during ion injection and cooling significantly reduces charge loss and signal drift in mass spectrometry.
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Bacteriophage T7's kinase modifies a large portion of the host proteome, with a focus on nucleic-acid-associated proteins, enhancing its ability to suppress bacterial defenses.
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A three-protein urinary signature effectively distinguishes clear cell renal cell carcinoma from healthy controls, showing promise for noninvasive cancer detection.
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A novel two-dimensional LC-MS workflow integrates untargeted metabolomics with targeted exposure measurements, allowing comprehensive analysis from a single sample.
