Ivermectin vs Permethrin for Scabies

Investigators evaluate household-level cure rates in dermoscopy-confirmed cases at day 28.

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1

Topical 5% permethrin cream showed higher clinical cure rates than oral ivermectin for classic scabies in a recent study.
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The SCRATCH trial analyzed 1,092 participants, revealing permethrin's statistical superiority at day 28 with an 88.5% cure rate.
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Cure rates for ivermectin were 71.8% overall, with a 16.7 percentage point difference compared to permethrin.
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Adverse events occurred in 9.9% of ivermectin cases and 13.6% of permethrin cases, with no serious events attributed to treatment.
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Factors like compliance, ease of use, and patient skin condition should guide treatment decisions for scabies.