Ivermectin vs Permethrin for Scabies - Takeaways - MDSpire

Ivermectin vs Permethrin for Scabies

Investigators evaluate household-level cure rates in dermoscopy-confirmed cases at day 28.

  • By

  • Kathryn Wighton

  • March 3, 2026

  • 3 min

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  • 1

    Topical 5% permethrin cream showed higher clinical cure rates than oral ivermectin for classic scabies in a recent study.

  • 2

    The SCRATCH trial analyzed 1,092 participants, revealing permethrin's statistical superiority at day 28 with an 88.5% cure rate.

  • 3

    Cure rates for ivermectin were 71.8% overall, with a 16.7 percentage point difference compared to permethrin.

  • 4

    Adverse events occurred in 9.9% of ivermectin cases and 13.6% of permethrin cases, with no serious events attributed to treatment.

  • 5

    Factors like compliance, ease of use, and patient skin condition should guide treatment decisions for scabies.

Original Source(s)

Ivermectin vs Permethrin for Scabies

  • by Kathryn Wighton

  • March 3, 2026

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