Loss of glymphatic homeostasis in heart failure

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Heart failure leads to reduced cerebral blood flow and cognitive decline, highlighting its impact on brain health.
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The glymphatic system is essential for brain waste clearance, and its dysfunction is linked to neurodegenerative diseases.
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In a mouse model, heart failure increased glymphatic influx but did not proportionately enhance protein clearance from the brain.
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Cerebral arterial pulsatility was found to be a major driver of glymphatic function, potentially explaining increased influx.
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The study suggests that impaired glymphatic function in heart failure may contribute to cognitive decline and neurodegeneration.

Brain

by Marios Kritsilis, Lotte Vanherle, Marko Rosenholm, René in ‘t Zandt, Yuan Yao, Kelley M Swanberg, Pia Weikop, Michael Gottschalk, Nagesh C Shanbhag, Jiebo Luo, Kimberly Boster, Maiken Nedergaard, Anja Meissner, Iben Lundgaard
December 18, 2024

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