Association of metabolic dysfunction-associated steatotic liver disease trajectories with incident liver cancer: a UK Biobank cohort study

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The study analyzed 12,111 participants from the UK Biobank to assess the link between MASLD and liver cancer incidence.
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At baseline, 33.1% of participants had MASLD, which was associated with a significantly higher risk of incident liver cancer.
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Cox proportional hazards models indicated that MASLD at both assessment periods was linked to increased liver cancer risk.
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Trajectory analyses revealed that both persistent MASLD and prior MASLD exposure were associated with higher liver cancer risk.
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The findings suggest that repeated assessment of MASLD may provide important prognostic information regarding liver cancer risk.

Frontiers In Endocrinology

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