Fluorescence-Guided Detection of Perineural and Bony Invasion With Margin Correlation in Gingival Squamous Cell Carcinoma Using Panitumumab-IRDye800 - Takeaways - MDSpire
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Fluorescence-Based Identification of Perineural and Bone Invasion with Margin Assessment in Gingival Squamous Cell Carcinoma Utilizing Panitumumab-IRDye800

  • By

  • Makenna Brown

  • Mabrooka Kazi

  • Hidenori Tanaka

  • Brandee Brown

  • Mitra Mehrad

  • Sarah Rohde

  • Eben Rosenthal

  • Kyle Mannion

  • June 14, 2026

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  • 1

    Negative margins in head and neck squamous cell carcinoma (HNSCC) are challenging, with 15%-30% of resections yielding close or positive margins.

  • 2

    Fluorescence-guided surgery (FGS) using panitumumab-IRDye800 improves intraoperative decision-making and has shown superior reproducibility compared to surgeon judgment.

  • 3

    Intraoperative fluorescence imaging revealed invasive squamous cell carcinoma involving the inferior alveolar nerve, confirming perineural invasion.

  • 4

    Final pathology indicated advanced disease with bony invasion and positive margins, leading to a recommendation for complete radical mandibulectomy.

  • 5

    This case demonstrates the potential of FGS to visualize tumor spread into bone and neural structures, aiding in the assessment of deeper margins.

Original Source(s)

Fluorescence-Guided Detection of Perineural and Bony Invasion With Margin Correlation in Gingival Squamous Cell Carcinoma Using Panitumumab-IRDye800

  • by Makenna Brown, Mabrooka Kazi, Hidenori Tanaka, Brandee Brown, Mitra Mehrad, Sarah Rohde, Eben Rosenthal, Kyle Mannion

  • June 14, 2026

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