The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation - Takeaways - MDSpire

The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation

  • By

  • Chuanlong Liu

  • Tonghao Wang

  • Zhishuai Ren

  • Ji Luo

  • Zhexiang Wang

  • Yanchen Liang

  • Bing Peng

  • May 20, 2026

  • 0 min

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  • 1

    Osteoporosis is a chronic metabolic bone disease characterized by low bone mass and deterioration of bone microarchitecture, primarily affecting the elderly and postmenopausal women.

  • 2

    Macrophages play a crucial role in osteoporosis by influencing osteoblast differentiation and bone resorption through their polarization states.

  • 3

    The imbalance between M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophage polarization contributes to the pathogenesis and progression of osteoporosis.

  • 4

    Modulating the M1/M2 polarization balance is significant for developing targeted therapeutic strategies for osteoporosis.

  • 5

    Emerging therapies, including conventional anti-osteoporotic drugs and novel technologies, aim to regulate macrophage polarization to improve osteoporosis treatment.

Original Source(s)

The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation

  • by Chuanlong Liu, Tonghao Wang, Zhishuai Ren, Ji Luo, Zhexiang Wang, Yanchen Liang, Bing Peng

  • May 20, 2026

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