Association of plasma homocysteine with the atherogenic index of plasma and modification by body mass index: a cross-sectional study - Takeaways - MDSpire

Association of plasma homocysteine with the atherogenic index of plasma and modification by body mass index: a cross-sectional study

  • By

  • Bin Jiang

  • Juan Yu

  • Chongxiang Chen

  • Yongshi Huang

  • July 15, 2026

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  • 1

    Plasma homocysteine (HCY) is positively correlated with the atherogenic index of plasma (AIP), indicating a potential risk factor for cardiovascular disease.

  • 2

    Each 1 μmol/L increase in HCY is associated with a 0.0113-unit increase in AIP and a higher likelihood of high AIP risk.

  • 3

    The relationship between HCY and AIP is stronger in participants with a body mass index (BMI) ≥ 24 kg/m compared to those with BMI < 24 kg/m.

  • 4

    Bootstrap mediation analyses did not find significant indirect effects of white blood cell count or alanine aminotransferase on the HCY-AIP relationship.

  • 5

    The study suggests that body mass index should be considered when evaluating the lipid-related atherogenic risk associated with elevated HCY.

Original Source(s)

Association of plasma homocysteine with the atherogenic index of plasma and modification by body mass index: a cross-sectional study

  • by Bin Jiang, Juan Yu, Chongxiang Chen, Yongshi Huang

  • July 15, 2026

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