Association of Serum and Aqueous Humor Levels of miR-199a-3p and FN1 with the Severity of Type 2 Diabetic Retinopathy in a Chinese Cohort - Takeaways - MDSpire

Association of Serum and Aqueous Humor Levels of miR-199a-3p and FN1 with the Severity of Type 2 Diabetic Retinopathy in a Chinese Cohort

  • By

  • Yang Chen

  • Nianlin Chen

  • Xiangrui Meng

  • Minli Linghu

  • Yikeng Huang

  • Xionggao Huang

  • April 28, 2026

  • 0 min

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  • 1

    Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness in the working-age population globally.

  • 2

    The study investigates the roles of miR-199a-3p and fibronectin 1 (FN1) in the progression of DR using bioinformatics and clinical validation.

  • 3

    miR-199a-3p is downregulated in high glucose conditions and may inhibit angiogenesis by targeting VEGF in diabetic retinopathy.

  • 4

    FN1 is implicated in fibrosis and inflammation, and its expression pattern in DR is explored to understand its regulatory mechanisms.

  • 5

    The research aims to identify novel biomarkers and therapeutic targets for early diagnosis and intervention in diabetic retinopathy.

Original Source(s)

Association of Serum and Aqueous Humor Levels of miR-199a-3p and FN1 with the Severity of Type 2 Diabetic Retinopathy in a Chinese Cohort

  • by Yang Chen, Nianlin Chen, Xiangrui Meng, Minli Linghu, Yikeng Huang, Xionggao Huang

  • April 28, 2026

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