Case Report: immune checkpoint inhibitor-associated aseptic meningitis in lung cancer: two cases illustrating an exclusion-based diagnosis approach and stepwise immunosuppressive treatment - Takeaways - MDSpire

Case Report: immune checkpoint inhibitor-associated aseptic meningitis in lung cancer: two cases illustrating an exclusion-based diagnosis approach and stepwise immunosuppressive treatment

  • By

  • Hiroshi Nakahama

  • Shigeo Hanada

  • Eisuke Takeda

  • Yui Takahashi

  • Yuichiro Nei

  • Takahiro Mitsumura

  • Atsushi Miyamoto

  • Meiyo Tamaoka

  • July 7, 2026

  • 0 min

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  • 1

    Immune checkpoint inhibitor-associated aseptic meningitis is a rare but serious neurological immune-related adverse event in lung cancer patients.

  • 2

    Two cases illustrate the importance of rapid exclusion of infectious meningitis and timely initiation of immunosuppressive therapy.

  • 3

    In Case 1, a 66-year-old woman improved significantly after high-dose intravenous methylprednisolone for suspected ICI-associated aseptic meningitis.

  • 4

    In Case 2, a 75-year-old man required additional tocilizumab after high-dose corticosteroids failed to halt neurological deterioration.

  • 5

    Cerebrospinal fluid multiplex polymerase chain reaction may aid in excluding treatable infections during the diagnostic evaluation.

Original Source(s)

Case Report: immune checkpoint inhibitor-associated aseptic meningitis in lung cancer: two cases illustrating an exclusion-based diagnosis approach and stepwise immunosuppressive treatment

  • by Hiroshi Nakahama, Shigeo Hanada, Eisuke Takeda, Yui Takahashi, Yuichiro Nei, Takahiro Mitsumura, Atsushi Miyamoto, Meiyo Tamaoka

  • July 7, 2026

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