Theoretical Framework for Immunologically Guided Skin Regeneration: Connecting Extracellular Matrix, Immune Response, and Skin Allografts

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Fibrosis characterizes adult skin healing, contrasting with regenerative capabilities seen in fetal wound healing and other biological systems.
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Immunoguided Cutaneous Regeneration (ICR) proposes that regeneration depends on the interaction between a preserved extracellular matrix and a regulated immune response.
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The ICR framework outlines four phases of regeneration: biological barrier, immune activation, selective epidermal elimination, and regenerative remodeling.
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The graft acts as a temporary microenvironment, facilitating recipient cell recruitment and tissue reorganization during the regeneration process.
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The ICR model synthesizes historical and experimental data, offering a structured platform for future research on skin allotransplantation and regeneration.

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