The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party - Takeaways - MDSpire

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party

  • By

  • Lars Klingen Gjærde

  • Tapani Ruutu

  • Christophe Peczynski

  • William Boreland

  • Nicolaus Kröger

  • Didier Blaise

  • Thomas Schroeder

  • Régis Peffault de Latour

  • Tobias Gedde-Dahl

  • Aleksandr Kulagin

  • Henrik Sengeløv

  • Ibrahim Yakoub-Agha

  • Jürgen Finke

  • Matthias Eder

  • Grzegorz Basak

  • Ivan Moiseev

  • Hélène Schoemans

  • Christian Koenecke

  • Olaf Penack

  • Zinaida Perić

  • December 7, 2023

  • 0 min

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  • 1

    Obesity and diabetes can lead to metabolic changes that affect immune responses and increase inflammation in allogeneic hematopoietic cell transplantation.

  • 2

    Pre-transplant obesity (BMI ≥ 30 kg/m2) may increase the risk of acute graft-versus-host disease (GvHD), though findings are inconsistent across studies.

  • 3

    Pre-transplant diabetes did not show a significant difference in acute GvHD risk compared to non-diabetic patients, but may increase GvHD-related mortality.

  • 4

    A recent EBMT study found low prevalence rates of pre-transplant diabetes (4.4%) and obesity (3.9%) among patients undergoing allogeneic HCT.

  • 5

    Further large registry studies are needed to clarify the impact of obesity and diabetes on acute GvHD and mortality in recent allogeneic HCT patients.

Original Source(s)

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party

  • by Lars Klingen Gjærde, Tapani Ruutu, Christophe Peczynski, William Boreland, Nicolaus Kröger, Didier Blaise, Thomas Schroeder, Régis Peffault de Latour, Tobias Gedde-Dahl, Aleksandr Kulagin, Henrik Sengeløv, Ibrahim Yakoub-Agha, Jürgen Finke, Matthias Eder, Grzegorz Basak, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, Olaf Penack, Zinaida Perić

  • December 7, 2023

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