Case Report: Marjolin ulcer characterized by squamous cell carcinoma arising from chronic wounds: clinical features, diagnostic and therapeutic challenges, and insights—a report of four cases - Takeaways - MDSpire

Case Report: Marjolin ulcer characterized by squamous cell carcinoma arising from chronic wounds: clinical features, diagnostic and therapeutic challenges, and insights—a report of four cases

  • By

  • Lianbo Yang

  • Xinming Wang

  • Wanchen Zhou

  • Jingyi Cui

  • Lili Niu

  • Mingyu Hu

  • Qi Liu

  • Haidong Liang

  • June 11, 2026

  • 0 min

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  • 1

    The study analyzed four cases of Marjolin ulcer, a type of cutaneous squamous cell carcinoma arising from chronic limb wounds.

  • 2

    All patients were initially misdiagnosed with benign chronic wounds, resulting in significant diagnostic delays ranging from months to decades.

  • 3

    Final pathology confirmed squamous cell carcinoma in all cases, with two patients exhibiting bone invasion.

  • 4

    Treatment escalated from local excision to amputation in three cases due to delayed diagnosis.

  • 5

    The study proposes clinical warning signals for early recognition of malignant transformation in chronic wounds.

Original Source(s)

Case Report: Marjolin ulcer characterized by squamous cell carcinoma arising from chronic wounds: clinical features, diagnostic and therapeutic challenges, and insights—a report of four cases

  • by Lianbo Yang, Xinming Wang, Wanchen Zhou, Jingyi Cui, Lili Niu, Mingyu Hu, Qi Liu, Haidong Liang

  • June 11, 2026

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