Association between circulating biomarkers of endothelial glycocalyx degradation and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass - Takeaways - MDSpire

Association between circulating biomarkers of endothelial glycocalyx degradation and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass

  • By

  • Minhuan Wang

  • Min He

  • Liyun Hong

  • Yafang Shen

  • Qin Wang

  • Yan Sun

  • July 13, 2026

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  • 1

    Postoperative acute kidney injury occurred in 28.3% of the 152 cardiac surgery patients studied.

  • 2

    Syndecan-1 and heparan sulfate levels increased significantly in patients with acute kidney injury during surgery.

  • 3

    Older age, longer aortic clamp time, and higher syndecan-1 levels were associated with postoperative acute kidney injury.

  • 4

    Syndecan-1 demonstrated the best discriminatory performance among biomarkers for predicting acute kidney injury.

  • 5

    The study highlights the potential role of glycocalyx degradation biomarkers in assessing renal risk during cardiac surgery.

Original Source(s)

Association between circulating biomarkers of endothelial glycocalyx degradation and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass

  • by Minhuan Wang, Min He, Liyun Hong, Yafang Shen, Qin Wang, Yan Sun

  • July 13, 2026

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