Stress-induced IL-6 regulation in pediatric bone growth disorders: current insights and therapeutic strategies

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Stress-induced IL-6 upregulation negatively impacts pediatric bone health by impairing skeletal growth and increasing fragility.
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Elevated IL-6 disrupts the GH/IGF-1 axis and enhances RANKL-mediated osteoclastogenesis, affecting bone density.
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Chronic IL-6 elevation impairs chondrocyte proliferation and differentiation, restricting longitudinal bone growth in children.
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Psychosocial stress activates pathways that elevate IL-6, leading to inflammatory responses that adversely affect bone health.
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Current research highlights the need for integrative therapies targeting inflammation to improve pediatric bone development.

Frontiers In Endocrinology

by Zaineb Sohail, Norhayati binti Abd. Hadi, Azizur Rehman, Muhammad Asghar, Farasat Zaman
June 2, 2026

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