Gut-Microbiota-Related Metabolite Phenylacetylglutamine and Risk of Incident Coronary Heart Disease Among Women - Takeaways - MDSpire

Gut-Microbiota-Related Metabolite Phenylacetylglutamine and Risk of Incident Coronary Heart Disease Among Women

  • By

  • Yoriko Heianza

  • Saumya Tiwari

  • Xuan Wang

  • Jeramie D Watrous

  • Kathryn M Rexrode

  • Frank B Hu

  • Mona Alotaibi

  • Mohit Jain

  • Qi Sun

  • JoAnn E Manson

  • Lu Qi

  • July 30, 2024

  • 0 min

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  • 1

    Higher plasma levels of phenylacetylglutamine (PAGln) are associated with an increased risk of coronary heart disease (CHD) in women.

  • 2

    The study involved 1520 women from the Nurses’ Health Study, with 760 incident CHD cases and 760 controls.

  • 3

    PAGln levels correlated with higher red/processed meat intake and lower vegetable intake among participants.

  • 4

    Adherence to a plant-based diet significantly modified the association between PAGln levels and CHD risk.

  • 5

    Women with low adherence to plant-based diets showed a higher risk of CHD associated with elevated PAGln levels.

Original Source(s)

Gut-Microbiota-Related Metabolite Phenylacetylglutamine and Risk of Incident Coronary Heart Disease Among Women

  • by Yoriko Heianza, Saumya Tiwari, Xuan Wang, Jeramie D Watrous, Kathryn M Rexrode, Frank B Hu, Mona Alotaibi, Mohit Jain, Qi Sun, JoAnn E Manson, Lu Qi

  • July 30, 2024

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