Musings from The Power List: Guinevere Lageveen-Kammeijer

How CE-MS is revealing the complexity of glycosylation – and why greater sensitivity must be matched by biological meaning

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Guinevere Lageveen-Kammeijer studies glycosylation and its changes in diseases such as cancer, using CE-MS-based glyco(proteo)omics.
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Her group aims to reveal previously hidden molecular details and extend glycomic analysis toward individual cells.
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She expects single-cell glycomics to reveal cellular heterogeneity and sees separation science, including CE-MS, as important for resolving molecular complexity.
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She emphasizes that greater sensitivity and more data do not automatically produce better science; measurements and computational patterns require validation and biological interpretation.
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A CE experiment using prostate-specific antigen as a model glycoprotein revealed CE's ability to separate glycoforms with differently linked sialic acids and redirected her PhD toward prostate cancer

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