Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles - Takeaways - MDSpire

Enhancing the Immunogenic Response of E. coli FimH through Multivalent Presentation on I53-50 Nanoparticles

  • By

  • Rebecca S. Cole

  • Natalie C. Silmon de Monerri

  • Jacqueline Lypowy

  • Christopher Ponce

  • Cara Kobylarz

  • Lily Liu

  • Zein Kasbo

  • Elizabeth Kepl

  • Tara Ciolino

  • Art Illenberger

  • Leslie Gallardo

  • Annalena Laporte

  • Danielle Baranova

  • Rashmi Ravichandran

  • Laurent O. Chorro

  • Robert G.K. Donald

  • Raphael Simon

  • Neil P. King

  • July 21, 2026

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  • 1

    Urinary tract infections, primarily caused by uropathogenic E. coli, affect approximately 50% of women globally.

  • 2

    FimH, an adhesin responsible for host receptor binding, is a promising vaccine candidate but is poorly immunogenic in its monomeric form.

  • 3

    Nanoparticle immunogens displaying FimH antigens on I53-50 elicited robust receptor-blocking antibodies in mice and non-human primates.

  • 4

    Both FimHLD and FimH-DSG displayed on I53-50 induced similar receptor-blocking activity as a higher dose of monomeric FimH-DSG with adjuvant.

  • 5

    The study demonstrates the potential of the I53-50 nanoparticle platform for enhancing the immunogenicity of bacterial antigens.

Original Source(s)

Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles

  • by Rebecca S. Cole, Natalie C. Silmon de Monerri, Jacqueline Lypowy, Christopher Ponce, Cara Kobylarz, Lily Liu, Zein Kasbo, Elizabeth Kepl, Tara Ciolino, Art Illenberger, Leslie Gallardo, Annalena Laporte, Danielle Baranova, Rashmi Ravichandran, Laurent O. Chorro, Robert G.K. Donald, Raphael Simon, Neil P. King

  • July 21, 2026

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