Transplacental transfer of anti-malarial antibodies: a systematic review - Takeaways - MDSpire

Transplacental transfer of anti-malarial antibodies: a systematic review

  • By

  • Abebe Muche Belete

  • Abdouramane Camara

  • Taklo Simeneh Yazie

  • Lucas N. Amenga-Etego

  • Yaw Aniweh

  • June 19, 2026

  • 0 min

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  • 1

    Pregnant women and young children are at the highest risk for malaria morbidity and mortality.

  • 2

    The systematic review included 42 studies with 8687 participants assessing transplacental antibody transfer against malaria.

  • 3

    Pooled prevalence of malaria was 31.27% in mothers, 30.65% in placentas, and 9.53% in newborns.

  • 4

    IgG1 and IgG3 were the most efficiently transferred antibody subclasses, with IgG against circumsporozoite protein showing higher transfer rates.

  • 5

    Factors like HIV infection, placental malaria, and low birth weight were associated with reduced maternal antibody transfer to newborns.

Original Source(s)

Transplacental transfer of anti-malarial antibodies: a systematic review

  • by Abebe Muche Belete, Abdouramane Camara, Taklo Simeneh Yazie, Lucas N. Amenga-Etego, Yaw Aniweh

  • June 19, 2026

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