Understanding the immune microenvironment of ovarian cancer

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Ovarian cancer is the most lethal gynecological malignancy, with immune checkpoint inhibitors showing limited efficacy due to CD8+ T cell exhaustion.
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Single-cell RNA sequencing has transformed the understanding of the tumor immune microenvironment by identifying rare immune subsets and their interactions.
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Terminally exhausted T cells in ovarian cancer evolve from GZMK+ progenitor populations, influenced by the immunomodulatory effects of ascitic fluid.
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Myeloid-lymphoid crosstalk in the tumor microenvironment contributes to localized immunosuppression and therapeutic resistance.
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High-resolution molecular insights from single-cell technologies are essential for predicting ICI responsiveness and developing precision immunotherapy.

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