GC×GC Detective Stories: Biomarkers, Biofuels, and Shape-Shifting Molecules - Takeaways - MDSpire
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GC×GC Detective Stories: Biomarkers, Biofuels, and Shape-Shifting Molecules

Philip Marriott, Renée Webster, and Konstantinos Kouremenos revisit three investigations in which an additional dimension of separation provided the information needed to solve three very different analytical mysteries

  • By

  • James Strachan

  • Frank van Geel

  • October 1, 2026

  • 15 min

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  • 1

    GC×GC revealed hidden chemical information in three cases, including a biomarker for a rare newborn metabolic disorder.

  • 2

    Crotonylglycine was identified as a novel urinary biomarker for HMGCS2 deficiency, previously obscured by a larger peak in one-dimensional GC-MS.

  • 3

    GC-MS remains the reference technique for urinary organic acid analysis, despite the advantages of LC-MS/MS for certain analytes.

  • 4

    The urinary organic acid profile for HMGCS2 deficiency can be transient, complicating diagnosis outside metabolic decompensation episodes.

  • 5

    Advances in chromatographic resolution have expanded the repertoire of biomarkers available for diagnosing inborn errors of metabolism.

Original Source(s)

GC×GC Detective Stories: Biomarkers, Biofuels, and Shape-Shifting Molecules

  • by James Strachan, Frank van Geel

  • October 1, 2026

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