Case Report: A unique case of Philadelphia chromosome-positive mixed-phenotype acute leukemia with active Epstein-Barr virus infection in a kidney transplantation recipient - Takeaways - MDSpire

Case Report: A unique case of Philadelphia chromosome-positive mixed-phenotype acute leukemia with active Epstein-Barr virus infection in a kidney transplantation recipient

  • By

  • Mengping Chen

  • Xuelian Hu

  • Weiying Feng

  • De Zhou

  • July 14, 2026

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  • 1

    Philadelphia chromosome-positive mixed-phenotype acute leukemia (Ph+ MPAL) is a rare and aggressive form of acute leukemia.

  • 2

    The case presented involves a kidney transplant patient with concurrent Ph+ MPAL and active Epstein-Barr virus (EBV) infection.

  • 3

    A tailored therapeutic strategy combined olverembatinib, dexamethasone, azacitidine, and lisaftoclax for leukemia treatment.

  • 4

    B-cell–depleting therapy with rituximab was used to address EBV viremia in the patient.

  • 5

    The integrated treatment approach successfully induced hematologic remission and cleared EBV viremia.

Original Source(s)

Case Report: A unique case of Philadelphia chromosome-positive mixed-phenotype acute leukemia with active Epstein-Barr virus infection in a kidney transplantation recipient

  • by Mengping Chen, Xuelian Hu, Weiying Feng, De Zhou

  • July 14, 2026

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