Investigating Genetic Factors that May Mediate the Link Between Obesity and Breast Cancer: A Two-Stage Mendelian Randomization Analysis - Takeaways - MDSpire

Investigating Genetic Factors that May Mediate the Link Between Obesity and Breast Cancer: A Two-Stage Mendelian Randomization Analysis

  • By

  • Yu Hao

  • Xia Jiang

  • Jinyu Xiao

  • Mengyu Fan

  • Xueyao Wu

  • Jiaqiang Liao

  • Xunying Zhao

  • Wanting Feng

  • Hongbo Qi

  • Jiayuan Li

  • March 10, 2026

  • 0 min

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  • 1

    Breast cancer is the most commonly diagnosed cancer in women, accounting for 24.5% of all female cancer cases in 2020.

  • 2

    Obesity is linked to breast cancer risk, particularly in postmenopausal women, but recent genetic analyses show an inverse association.

  • 3

    Mendelian randomization (MR) can clarify the causal mediating roles of biomarkers in the relationship between BMI and breast cancer.

  • 4

    The study evaluates eight circulating biomarkers related to obesity and breast cancer using MR to understand their mediation effects.

  • 5

    Data for the study were sourced from large GWAS involving over 133,000 breast cancer cases and 113,000 controls, focusing on European women.

Original Source(s)

Investigating Genetic Factors that May Mediate the Link Between Obesity and Breast Cancer: A Two-Stage Mendelian Randomization Analysis

  • by Yu Hao, Xia Jiang, Jinyu Xiao, Mengyu Fan, Xueyao Wu, Jiaqiang Liao, Xunying Zhao, Wanting Feng, Hongbo Qi, Jiayuan Li

  • March 10, 2026

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