Exploratory analysis of neutrophil extracellular traps in synovial fluid and plasma from children with juvenile idiopathic arthritis

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The study investigates neutrophil-and platelet-derived extracellular vesicles in children with juvenile idiopathic arthritis (JIA).
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Seven children with active, untreated JIA and ten healthy controls were included in the exploratory pilot study.
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Neutrophil-and platelet-associated extracellular vesicles were found in both plasma and synovial fluid of all JIA patients.
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Plasma levels of CD41+ and MPO+ extracellular vesicles were significantly higher in the JIA group compared to controls.
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The study indicates systemic platelet activation and neutrophil extracellular trap-related activity in JIA patients.

Frontiers In Pediatrics

by Berntson, Lillemor , Sandström, Caroline , Elfving, Andreas , Mobarrez, Fariborz
June 24, 2026

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