CD4+ T cell signature in long COVID: insights from an unvaccinated cohort - Takeaways - MDSpire

CD4+ T cell signature in long COVID: insights from an unvaccinated cohort

  • By

  • Thiago Cerqueira-Silva

  • Benjamin Goodwin

  • Cíntia Araújo

  • Jessica J. Silva

  • Blenda de J. Pereira

  • Ícaro Bonyek Santos da Silva

  • Sara Nunes

  • Ananda Marinho

  • Ana Paula Barreto

  • Marcio Barreto

  • Marcelo Chalhoub

  • Juliana Ribeiro Caldas

  • Vishal Rao

  • Camila Coelho

  • Adolfo Rojas-Hidalgo

  • Vinicius Maracaja-Coutinho

  • Ricardo Khouri

  • Cristina R. Cardoso

  • Aldina Barral

  • Manoel Barral-Netto

  • Natalia Machado Tavares

  • Jennifer Dan

  • Viviane S. Boaventura

  • June 29, 2026

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  • 1

    The study analyzed immune responses in a Brazilian cohort of unvaccinated patients with Long COVID (LC) and recovered controls (RC).

  • 2

    Systemic humoral responses to SARS-CoV-2 were similar in LC and RC groups, but distinct immune signatures were identified in CD4+ T cells.

  • 3

    LC patients exhibited a signature of acute activation in CD4+ T cells, with upregulation of genes like CD38 and interferon-stimulated genes.

  • 4

    Gene set enrichment analysis indicated increased expression of interferon-alpha/gamma signatures in LC patients compared to RC.

  • 5

    The findings suggest that LC immunopathology involves qualitative T cell dysfunction characterized by non-proliferative activation.

Original Source(s)

CD4+ T cell signature in long COVID: insights from an unvaccinated cohort

  • by Thiago Cerqueira-Silva, Benjamin Goodwin, Cíntia Araújo, Jessica J. Silva, Blenda de J. Pereira, Ícaro Bonyek Santos da Silva, Sara Nunes, Ananda Marinho, Ana Paula Barreto, Marcio Barreto, Marcelo Chalhoub, Juliana Ribeiro Caldas, Vishal Rao, Camila Coelho, Adolfo Rojas-Hidalgo, Vinicius Maracaja-Coutinho, Ricardo Khouri, Cristina R. Cardoso, Aldina Barral, Manoel Barral-Netto, Natalia Machado Tavares, Jennifer Dan, Viviane S. Boaventura

  • June 29, 2026

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