Collagenase Effective for Recurrent Dupuytren

Collagenase treatment improves contracture recurrence in patients after prior surgery

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Collagenase clostridium histolyticum is a safe and effective nonsurgical treatment for recurrent Dupuytren contracture post-surgery.
2

The study involved 101 patients, with a median recurrence time of 36 months after initial surgery, primarily affecting men.
3

Treatment with collagenase resulted in an average contracture improvement of 38° within 12 months, with better outcomes in metacarpophalangeal joints.
4

Clinical success was achieved in 65% of joints at the first evaluation and 58% at the final evaluation, with notable differences between joint types.
5

Adverse events occurred in 36% of patients, with skin tears being the most common complication, all of which healed spontaneously.

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