The high-risk phenotype for gastrointestinal vulnerability in sepsis and 28-day mortality: an integrative study based on clinical association and cross-level biological support - Takeaways - MDSpire

The high-risk phenotype for gastrointestinal vulnerability in sepsis and 28-day mortality: an integrative study based on clinical association and cross-level biological support

  • By

  • Congcong Qin

  • Weiwei Wang

  • Qinyuan Du

  • Li Kong

  • Batejin

  • Shuanglin Zhang

  • Guochen Li

  • June 30, 2026

  • 0 min

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  • 1

    Gastrointestinal dysfunction is common in sepsis but often inadequately represented in organ-specific risk stratification.

  • 2

    The study defined a gastrointestinal vulnerability phenotype (GIVP) high-risk using electronic health record data to evaluate its prognostic relevance.

  • 3

    In the primary analysis, GIVP high-risk was associated with 28-day mortality, retaining significance after adjusting for various clinical factors.

  • 4

    Incremental prediction analysis showed minimal improvement in discrimination, particularly in high-severity subgroups.

  • 5

    Cross-level analyses indicated biological plausibility, aligning GIVP high-risk with inflammatory patterns and abnormal tissue remodeling.

Original Source(s)

The high-risk phenotype for gastrointestinal vulnerability in sepsis and 28-day mortality: an integrative study based on clinical association and cross-level biological support

  • by Congcong Qin, Weiwei Wang, Qinyuan Du, Li Kong, Batejin, Shuanglin Zhang, Guochen Li

  • June 30, 2026

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