Diagnostic Difficulties in Primary Pulmonary Follicular Dendritic Cell Sarcoma: A Report of Two Cases

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Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor primarily found in lymph nodes but can also occur in the lungs.
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Two cases of primary pulmonary FDCS were analyzed, highlighting diagnostic challenges and the importance of accurate histopathological evaluation.
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Histological features of FDCS include nest-like structures, diffuse cell distribution, and abundant small lymphocyte infiltration.
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Both patients underwent surgery and adjuvant chemotherapy, showing no evidence of disease recurrence or metastasis during follow-up.
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A literature review identified 11 additional cases of primary pulmonary FDCS, indicating a male predominance and relatively favorable prognosis.

Bmc Pulmonary Medicine

by Dongmei Ye, Xinyan Huang, Luoyan Wu, Minshi Ye, Zhaokang Zhou, Liping Xu, Yong Liu
February 10, 2026

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