New indicators of Alzheimer's risk may be linked to brain blood flow and oxygen delivery, as per a study using noninvasive cerebrovascular measurements.
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Researchers combined ultrasound and optical measurements to identify cerebrovascular indicators that align with established Alzheimer's neuroimaging markers.
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Higher cerebrovascular indicator values were associated with lower amyloid burden and larger hippocampal volume, indicating lower Alzheimer's risk.
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Participants with mild cognitive impairment or dementia exhibited poorer cerebrovascular indicators compared to cognitively normal adults.
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The study suggests that noninvasive cerebrovascular measurements could complement existing imaging approaches for Alzheimer's disease.
