A systematic review and meta-analysis of bacterial pathogen prevalence in acute and chronic rhinosinusitis: implications for empiric antibiotic therapy and antimicrobial stewardship - Takeaways - MDSpire
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A comprehensive review and meta-analysis of the prevalence of bacterial pathogens in acute and chronic rhinosinusitis: considerations for empirical antibiotic treatment and antimicrobial stewardship

  • By

  • Hye Ok Kim

  • Suhyeon Ha

  • Jung Jae Shim

  • Eunyoung Tak

  • Jung-Man Namgoong

  • August 11, 2026

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  • 1

    In the US, sinusitis—including acute and chronic forms—affects approximately 15% of the population, or more than 35 million people annually.

  • 2

    More than 90% of sinusitis cases are viral, and approximately 0.5% to 2% of adult viral cases develop secondary acute bacterial rhinosinusitis.

  • 3

    Chronic rhinosinusitis involves persistent sinonasal inflammation and symptoms lasting at least 12 weeks and has a complex, multifactorial etiology; many cases are associated with microbial dysbiosis.

  • 4

    Acute and chronic rhinosinusitis have markedly different bacterial profiles; coagulase-negative staphylococci and methicillin-susceptible *Staphylococcus aureus* predominated in chronic rhinosinusitis.

  • 5

    This systematic review and meta-analysis aimed to compare bacterial pathogen profiles in acute vs chronic rhinosinusitis.

Original Source(s)

A systematic review and meta-analysis of bacterial pathogen prevalence in acute and chronic rhinosinusitis: implications for empiric antibiotic therapy and antimicrobial stewardship

  • by Hye Ok Kim, Suhyeon Ha, Jung Jae Shim, Eunyoung Tak, Jung-Man Namgoong

  • August 11, 2026

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